Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-mazE/upstrm_HI1419-MazF
Location 1045822..1046550 Replicon chromosome
Accession NZ_CP070959
Organism Thiomicrospira microaerophila strain BDL05

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JX580_RS04965 Protein ID WP_248851695.1
Coordinates 1046251..1046550 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JX580_RS04960 Protein ID WP_248851694.1
Coordinates 1045822..1046130 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JX580_RS04930 (JX580_04940) 1040946..1042280 + 1335 WP_248851689.1 replication-associated recombination protein A -
JX580_RS04935 (JX580_04945) 1042282..1042662 + 381 WP_248851690.1 fluoride efflux transporter CrcB -
JX580_RS04940 (JX580_04950) 1042696..1043985 + 1290 WP_248851691.1 serine--tRNA ligase -
JX580_RS04950 (JX580_04960) 1044513..1044899 + 387 WP_248851692.1 tyrosine-type recombinase/integrase -
JX580_RS04955 (JX580_04965) 1045589..1045828 + 240 WP_248851693.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JX580_RS04960 (JX580_04970) 1045822..1046130 + 309 WP_248851694.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
JX580_RS04965 (JX580_04975) 1046251..1046550 + 300 WP_248851695.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JX580_RS04970 (JX580_04980) 1046553..1046837 + 285 WP_248851696.1 putative addiction module antidote protein -
JX580_RS04975 (JX580_04990) 1047080..1047250 - 171 WP_248851697.1 hypothetical protein -
JX580_RS04980 (JX580_04995) 1047280..1048372 - 1093 Protein_959 IS3 family transposase -
JX580_RS04985 (JX580_05000) 1048421..1049083 + 663 WP_248851698.1 hypothetical protein -
JX580_RS04990 (JX580_05005) 1049310..1049483 - 174 WP_248851699.1 hypothetical protein -
JX580_RS04995 (JX580_05010) 1049508..1049744 - 237 WP_248851700.1 hypothetical protein -
JX580_RS05000 (JX580_05015) 1049934..1051016 - 1083 WP_248851701.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1040946..1048372 7426
- flank IS/Tn - - 1047280..1047537 257


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-92)

Antitoxin

mRNA interferase PemK-like

(4-92)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11629.37 Da        Isoelectric Point: 10.3533

>T194784 WP_248851695.1 NZ_CP070959:1046251-1046550 [Thiomicrospira microaerophila]
MKYRILTTTKFDKWFKSIKDKMTRYRLEARINQVARGNFGDWKPIDSNVNELRFFFAGGVRIYYIIRENEIVLLLNGGDK
STQSRDIATAKDLFSQLGE

Download         Length: 300 bp

>T194784 NZ_CP094065:20457-21239 [Helicobacter pylori]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
TCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAGGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAGGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAGAAGAGGAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACTTATTTTTTGGTTTAATCTGATGGTTACAATCCTATTTGTGATTGGTTTTGTG
GGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11472.62 Da        Isoelectric Point: 10.9824

>AT194784 WP_248851694.1 NZ_CP070959:1045822-1046130 [Thiomicrospira microaerophila]
VVSRGDVYWVELDPTLGSEISKTRPCLIVSPDDMNNSLPRVIVAPITSKGQPLGCRPETTLAGKQARILLDQVRRIDKRR
LKKKLGVIPLAVWHKTLIRMFT

Download         Length: 309 bp

>AT194784 NZ_CP094065:20030-20467 [Helicobacter pylori]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCGTTCAAACAAAGGATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAATTGGAAACCATCAACTACTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References