Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-DnaT |
| Location | 45447..45969 | Replicon | plasmid pTB44P3 |
| Accession | NZ_CP070957 | ||
| Organism | Escherichia fergusonii strain EF44 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | U9YLU1 |
| Locus tag | JYG65_RS22930 | Protein ID | WP_000638823.1 |
| Coordinates | 45688..45969 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U9Y7J1 |
| Locus tag | JYG65_RS22925 | Protein ID | WP_000121741.1 |
| Coordinates | 45447..45698 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JYG65_RS22870 (JYG65_22775) | 40536..40979 | + | 444 | WP_000964330.1 | NfeD family protein | - |
| JYG65_RS22875 (JYG65_22780) | 40983..41153 | + | 171 | WP_000550720.1 | hypothetical protein | - |
| JYG65_RS22880 (JYG65_22785) | 41164..41610 | + | 447 | WP_001243165.1 | hypothetical protein | - |
| JYG65_RS22885 (JYG65_22790) | 41643..41900 | + | 258 | WP_001542015.1 | hypothetical protein | - |
| JYG65_RS22890 (JYG65_22795) | 41881..42183 | + | 303 | WP_001360345.1 | hypothetical protein | - |
| JYG65_RS22895 (JYG65_22800) | 42180..42437 | + | 258 | WP_000739144.1 | hypothetical protein | - |
| JYG65_RS22900 (JYG65_22805) | 42441..43436 | + | 996 | WP_001028543.1 | type IV secretion system protein | - |
| JYG65_RS22905 (JYG65_22810) | 43442..44083 | + | 642 | WP_001425343.1 | type IV secretion system protein | - |
| JYG65_RS22910 (JYG65_22815) | 44085..44339 | + | 255 | WP_001043555.1 | EexN family lipoprotein | - |
| JYG65_RS22915 (JYG65_22820) | 44352..44639 | + | 288 | WP_001032611.1 | EexN family lipoprotein | - |
| JYG65_RS22920 (JYG65_22825) | 44712..45347 | + | 636 | WP_015059536.1 | hypothetical protein | - |
| JYG65_RS22925 (JYG65_22830) | 45447..45698 | + | 252 | WP_000121741.1 | hypothetical protein | Antitoxin |
| JYG65_RS22930 (JYG65_22835) | 45688..45969 | + | 282 | WP_000638823.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JYG65_RS22935 (JYG65_22840) | 46037..46336 | + | 300 | WP_000835764.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| JYG65_RS22940 (JYG65_22845) | 46339..47574 | + | 1236 | WP_015059538.1 | TcpQ domain-containing protein | - |
| JYG65_RS22945 (JYG65_22850) | 47580..48017 | + | 438 | WP_000539665.1 | type IV pilus biogenesis protein PilM | - |
| JYG65_RS22950 (JYG65_22855) | 48136..48534 | + | 399 | WP_001153665.1 | hypothetical protein | - |
| JYG65_RS22955 (JYG65_22860) | 48555..49139 | + | 585 | WP_001177113.1 | lytic transglycosylase domain-containing protein | - |
| JYG65_RS22960 | 49139..49429 | + | 291 | WP_000865479.1 | conjugal transfer protein | - |
| JYG65_RS22965 (JYG65_22870) | 49500..49820 | + | 321 | WP_000362080.1 | VirB3 family type IV secretion system protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..62882 | 62882 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10945.79 Da Isoelectric Point: 10.4997
>T194782 WP_000638823.1 NZ_CP070957:45688-45969 [Escherichia fergusonii]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR
Download Length: 282 bp
>T194782 NZ_CP094063:573811-574083 [Helicobacter pylori]
ATGTTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCCTTTTA
GTAAGGTTAGGTAGTCATAGCGAGCTGTTTTAA
ATGTTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCCTTTTA
GTAAGGTTAGGTAGTCATAGCGAGCTGTTTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9223.38 Da Isoelectric Point: 3.9823
>AT194782 WP_000121741.1 NZ_CP070957:45447-45698 [Escherichia fergusonii]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL
Download Length: 252 bp
>AT194782 NZ_CP094063:573513-573824 [Helicobacter pylori]
ATGCCTAACTCTCACACCAAAAAAGACTACACACGATACAACGAAAAACAGCTTTTTAACTTTTTAAATTCCATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CACTCCATTTAACCGAAAACGGATACACCCTAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAAAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGTTGATGATTGA
ATGCCTAACTCTCACACCAAAAAAGACTACACACGATACAACGAAAAACAGCTTTTTAACTTTTTAAATTCCATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CACTCCATTTAACCGAAAACGGATACACCCTAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAAAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGTTGATGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|