Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 28344..28845 | Replicon | plasmid pTB44P3 |
| Accession | NZ_CP070957 | ||
| Organism | Escherichia fergusonii strain EF44 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | JYG65_RS22780 | Protein ID | WP_000702247.1 |
| Coordinates | 28585..28845 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | JYG65_RS22775 | Protein ID | WP_001132407.1 |
| Coordinates | 28344..28595 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JYG65_RS22735 (JYG65_22655) | 23401..24153 | + | 753 | WP_063078685.1 | conjugal transfer protein TraL | - |
| JYG65_RS22740 (JYG65_22660) | 24155..24862 | + | 708 | WP_021503228.1 | hypothetical protein | - |
| JYG65_RS22745 (JYG65_22665) | 24882..25208 | + | 327 | WP_063078684.1 | hypothetical protein | - |
| JYG65_RS22750 (JYG65_22670) | 25339..25776 | - | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JYG65_RS22755 (JYG65_22675) | 25801..25983 | - | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| JYG65_RS22760 | 26280..26723 | + | 444 | WP_000068545.1 | hypothetical protein | - |
| JYG65_RS22765 (JYG65_22685) | 26830..27096 | - | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JYG65_RS22770 (JYG65_22690) | 27516..27794 | - | 279 | WP_000545938.1 | hypothetical protein | - |
| JYG65_RS22775 (JYG65_22695) | 28344..28595 | - | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| JYG65_RS22780 (JYG65_22700) | 28585..28845 | - | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| JYG65_RS22785 (JYG65_22705) | 28897..29121 | - | 225 | WP_000814381.1 | hypothetical protein | - |
| JYG65_RS22790 (JYG65_22710) | 29218..29427 | - | 210 | WP_000866036.1 | hypothetical protein | - |
| JYG65_RS22795 (JYG65_22715) | 29628..30738 | - | 1111 | Protein_34 | IS4-like element IS421 family transposase | - |
| JYG65_RS22800 (JYG65_22720) | 30816..31139 | - | 324 | WP_000427403.1 | hypothetical protein | - |
| JYG65_RS22805 (JYG65_22725) | 31721..32049 | - | 329 | Protein_36 | hypothetical protein | - |
| JYG65_RS22810 | 32643..32870 | + | 228 | WP_001415811.1 | P-loop NTPase | - |
| JYG65_RS22815 | 32885..33307 | + | 423 | WP_032163980.1 | hypothetical protein | - |
| JYG65_RS22820 (JYG65_22735) | 33381..33665 | + | 285 | WP_001162371.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..62882 | 62882 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T194781 WP_000702247.1 NZ_CP070957:c28845-28585 [Escherichia fergusonii]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T194781 NZ_CP094063:573060-573344 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT194781 WP_001132407.1 NZ_CP070957:c28595-28344 [Escherichia fergusonii]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT194781 NZ_CP094063:572687-573079 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAGCTTAATCAATCAATTAGAGCA
AAAAATCAAAAGGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTGTTGCTTT
GGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATGGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA
ATGCCTAACTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAGCTTAATCAATCAATTAGAGCA
AAAAATCAAAAGGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATAATAAAAGAGATTGTTGCTTT
GGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATGGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|