Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 15709..16352 Replicon plasmid pTB44P1
Accession NZ_CP070955
Organism Escherichia fergusonii strain EF44

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag JYG65_RS21335 Protein ID WP_001044768.1
Coordinates 15709..16125 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag JYG65_RS21340 Protein ID WP_001261287.1
Coordinates 16122..16352 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG65_RS21320 (JYG65_21240) 12208..12798 - 591 WP_000194575.1 hypothetical protein -
JYG65_RS21325 (JYG65_21245) 12798..13055 - 258 WP_000343085.1 hypothetical protein -
JYG65_RS21330 (JYG65_21250) 13409..15547 + 2139 WP_000350638.1 AAA family ATPase -
JYG65_RS21335 (JYG65_21255) 15709..16125 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
JYG65_RS21340 (JYG65_21260) 16122..16352 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JYG65_RS21345 (JYG65_21265) 16648..16938 + 291 WP_000111771.1 hypothetical protein -
JYG65_RS21350 (JYG65_21270) 16928..17827 + 900 WP_000963206.1 nucleotide-binding protein -
JYG65_RS21355 (JYG65_21275) 17877..20102 - 2226 WP_000698737.1 P-loop NTPase fold protein -
JYG65_RS21360 (JYG65_21280) 20104..21192 - 1089 WP_000952217.1 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) / sitABCD / aadA5 - 1..143778 143778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T194778 WP_001044768.1 NZ_CP070955:c16125-15709 [Escherichia fergusonii]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T194778 NZ_CP094061:572074-572340 [Helicobacter pylori]
GTGTTAAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCACTAGACCCCCAATTTAAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGCAAGATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT194778 WP_001261287.1 NZ_CP070955:c16352-16122 [Escherichia fergusonii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT194778 NZ_CP094061:572419-572730 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAATATAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGTTGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References