Detailed information of TA system TA194777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3995947..3996469
• Replicon: chromosome
• Accession: NZ_CP070954
• Organism: Escherichia fergusonii strain EF44

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JYG65_RS19055
• Protein ID: WP_180491929.1
• Coordinates: 3995947..3996237 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V0SC69
• Locus tag: JYG65_RS19060
• Protein ID: WP_000212715.1
• Coordinates: 3996227..3996469 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYG65_RS19040 (3991110)	3991110..3992765	+	1656	WP_223666567.1	alpha,alpha-phosphotrehalase	-
JYG65_RS19045 (3993159)	3993159..3995297	+	2139	WP_000187805.1	anaerobic ribonucleoside-triphosphate reductase	-
JYG65_RS19050 (3995482)	3995482..3995946	+	465	WP_001106232.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JYG65_RS19055 (3995947)	3995947..3996237	-	291	WP_180491929.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JYG65_RS19060 (3996227)	3996227..3996469	-	243	WP_000212715.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JYG65_RS19065 (3996660)	3996660..3997046	-	387	WP_001232246.1	cytochrome b562	-
JYG65_RS19070 (3997099)	3997099..3998451	-	1353	WP_001162171.1	metalloprotease PmbA	-
JYG65_RS19075 (3998545)	3998545..3999096	+	552	WP_000166270.1	ribosome biogenesis factor YjgA	-
JYG65_RS19080 (3999179)	3999179..4000552	-	1374	WP_223666568.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11350.29 Da
• Isoelectric Point: 10.3889

>T194777 WP_180491929.1 NZ_CP070954:c3996237-3995947 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVKVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELIVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T194777 NZ_CP094061:572074-572340 [Helicobacter pylori]
GTGTTAAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAGAAAGAACCACTAGACCCCCAATTTAAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGCAAGATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9125.56 Da
• Isoelectric Point: 5.1369

>AT194777 WP_000212715.1 NZ_CP070954:c3996469-3996227 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT194777 NZ_CP094061:571716-572093 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAATTTAATCAACCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGACAAAAGGGATCAAAACT
TTAAAGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGCTTT
GGGCATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAACCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U9H4B3