Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1068340..1069040 Replicon chromosome
Accession NZ_CP070954
Organism Escherichia fergusonii strain EF44

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8S7EAY2
Locus tag JYG65_RS05140 Protein ID WP_047644098.1
Coordinates 1068717..1069040 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7EES4
Locus tag JYG65_RS05135 Protein ID WP_047644099.1
Coordinates 1068340..1068696 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYG65_RS05095 (1063379) 1063379..1064254 + 876 WP_223671512.1 GTPase family protein -
JYG65_RS05100 (1064469) 1064469..1065176 + 708 WP_058687319.1 WYL domain-containing protein -
JYG65_RS05105 (1065173) 1065173..1065631 + 459 WP_058687320.1 hypothetical protein -
JYG65_RS05110 (1065651) 1065651..1066121 + 471 WP_058687321.1 hypothetical protein -
JYG65_RS05115 (1066246) 1066246..1067067 + 822 WP_223671513.1 DUF932 domain-containing protein -
JYG65_RS05120 (1067098) 1067098..1067541 + 444 WP_058687323.1 antirestriction protein -
JYG65_RS05125 (1067554) 1067554..1068096 + 543 WP_063851287.1 DNA repair protein RadC -
JYG65_RS05130 (1068093) 1068093..1068314 + 222 WP_047644100.1 DUF987 family protein -
JYG65_RS05135 (1068340) 1068340..1068696 + 357 WP_047644099.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JYG65_RS05140 (1068717) 1068717..1069040 + 324 WP_047644098.1 TA system toxin CbtA family protein Toxin
JYG65_RS05145 (1069405) 1069405..1069674 + 270 Protein_1006 Arm DNA-binding domain-containing protein -
JYG65_RS05150 (1069859) 1069859..1070104 - 246 WP_148713330.1 hypothetical protein -
JYG65_RS05155 (1070335) 1070335..1073658 + 3324 WP_223671517.1 inverse autotransporter beta domain-containing protein -
JYG65_RS05160 (1073773) 1073773..1073961 + 189 WP_015953670.1 PerC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1048562..1069040 20478


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12530.57 Da        Isoelectric Point: 7.1331

>T194759 WP_047644098.1 NZ_CP070954:1068717-1069040 [Escherichia fergusonii]
MKFLPTTNMRAAKPCLSPVTIWQMLLSRLLEQHYGLTLNDTPFCDETVIQEHIDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTFIDIMRARRDLGLMNRN

Download         Length: 324 bp

>T194759 NZ_CP093966:c4396016-4395261 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGTGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAACTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13155.84 Da        Isoelectric Point: 5.8766

>AT194759 WP_047644099.1 NZ_CP070954:1068340-1068696 [Escherichia fergusonii]
MNNHSESGAIPENPPCQQWGLKSTITPCFGARLVQEGDRLHFLADRAGFNGAFSDEHALRLDQAFPLILKQLELILTSGE
LSPRHQHCVTLYHNELTCEADTLGSCGYVYIAIYPTQR

Download         Length: 357 bp

>AT194759 NZ_CP093966:c4396518-4396150 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References