Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 509258..509780 Replicon chromosome
Accession NZ_CP070951
Organism Escherichia fergusonii strain EF31

Toxin (Protein)


Gene name relE Uniprot ID A0A7W3EN85
Locus tag JW961_RS02410 Protein ID WP_046083069.1
Coordinates 509490..509780 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F0JQI5
Locus tag JW961_RS02405 Protein ID WP_000212719.1
Coordinates 509258..509500 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW961_RS02385 (505175) 505175..506548 + 1374 WP_223662921.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
JW961_RS02390 (506631) 506631..507182 - 552 WP_088167473.1 ribosome biogenesis factor YjgA -
JW961_RS02395 (507276) 507276..508628 + 1353 WP_001162171.1 metalloprotease PmbA -
JW961_RS02400 (508681) 508681..509067 + 387 WP_001232246.1 cytochrome b562 -
JW961_RS02405 (509258) 509258..509500 + 243 WP_000212719.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JW961_RS02410 (509490) 509490..509780 + 291 WP_046083069.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW961_RS02415 (509781) 509781..510245 - 465 WP_001106232.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JW961_RS02420 (510403) 510403..512541 - 2139 WP_000187805.1 anaerobic ribonucleoside-triphosphate reductase -
JW961_RS02425 (512934) 512934..514589 - 1656 WP_223662919.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11323.22 Da        Isoelectric Point: 10.3007

>T194725 WP_046083069.1 NZ_CP070951:509490-509780 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T194725 NZ_CP093935:c2559497-2559231 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9124.62 Da        Isoelectric Point: 8.5314

>AT194725 WP_000212719.1 NZ_CP070951:509258-509500 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRKRLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT194725 NZ_CP093935:c2559754-2559497 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3EN85

Antitoxin

Source ID Structure
AlphaFold DB F0JQI5

References