194700

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 22878..23400 Replicon plasmid p40EC-5
Accession NZ_CP070925
Organism Escherichia coli strain 40EC

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag JR909_RS25315 Protein ID WP_000220560.1
Coordinates 22878..23159 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag JR909_RS25320 Protein ID WP_000121743.1
Coordinates 23149..23400 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR909_RS25270 17887..18378 - 492 WP_000872475.1 transcription termination factor NusG -
JR909_RS25275 18739..19896 - 1158 WP_000538023.1 hypothetical protein -
JR909_RS25280 19899..20444 - 546 WP_038976855.1 hypothetical protein -
JR909_RS25285 20771..21043 - 273 WP_000160399.1 hypothetical protein -
JR909_RS25290 21056..21205 - 150 WP_000003880.1 hypothetical protein -
JR909_RS25295 21492..21821 - 330 WP_000866648.1 hypothetical protein -
JR909_RS25300 21914..22129 - 216 WP_001180116.1 hypothetical protein -
JR909_RS25305 22119..22364 - 246 WP_000356546.1 hypothetical protein -
JR909_RS25310 22409..22732 - 324 WP_001181903.1 hypothetical protein -
JR909_RS25315 22878..23159 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR909_RS25320 23149..23400 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
JR909_RS25325 24678..25514 + 837 WP_001050931.1 replication initiation protein -
JR909_RS25330 25554..26000 + 447 WP_001074386.1 hypothetical protein -
JR909_RS25335 26068..26490 + 423 WP_031942371.1 DNA distortion polypeptide 3 -
JR909_RS25340 26550..27518 - 969 WP_077249520.1 IS5-like element IS903B family transposase -
JR909_RS25345 27520..27813 - 294 WP_015060510.1 hypothetical protein -
JR909_RS25350 27829..28059 - 231 WP_000051064.1 partitioning protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / qnrS1 / dfrA14 - 1..50323 50323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T194700 WP_000220560.1 NZ_CP070925:c23159-22878 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T194700 NZ_CP093930:c2523394-2523287 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT194700 WP_000121743.1 NZ_CP070925:c23400-23149 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT194700 NZ_CP093930:2523210-2523270 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References