194698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 7053..7546 Replicon plasmid p40EC-4
Accession NZ_CP070924
Organism Escherichia coli strain 40EC

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag JR909_RS24865 Protein ID WP_001230709.1
Coordinates 7053..7307 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag JR909_RS24870 Protein ID WP_000151456.1
Coordinates 7304..7546 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR909_RS24830 2628..2789 + 162 WP_001366886.1 type I toxin-antitoxin system Hok family toxin -
JR909_RS24835 2939..3535 + 597 WP_000125165.1 hypothetical protein -
JR909_RS24840 3553..3837 - 285 WP_001162371.1 hypothetical protein -
JR909_RS24845 3911..4576 - 666 WP_000532149.1 P-loop NTPase -
JR909_RS24850 5165..5494 + 330 WP_001542022.1 hypothetical protein -
JR909_RS24855 5895..6410 + 516 WP_001025393.1 J domain-containing protein -
JR909_RS24860 6514..7056 + 543 WP_001083904.1 hypothetical protein -
JR909_RS24865 7053..7307 + 255 WP_001230709.1 hypothetical protein Toxin
JR909_RS24870 7304..7546 + 243 WP_000151456.1 hypothetical protein Antitoxin
JR909_RS24875 8117..8410 + 294 WP_000673428.1 hypothetical protein -
JR909_RS24880 8899..9147 + 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin -
JR909_RS24885 9144..9491 + 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin -
JR909_RS24890 9579..9761 - 183 WP_001428470.1 hypothetical protein -
JR909_RS24895 10263..10562 + 300 WP_034169410.1 type II toxin-antitoxin system HicB family antitoxin -
JR909_RS24900 10822..11148 - 327 WP_000206697.1 hypothetical protein -
JR909_RS24905 11150..11590 - 441 WP_023223352.1 hypothetical protein -
JR909_RS24910 11610..12317 - 708 WP_000108794.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid mcr-1.1 - 1..60993 60993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9942.47 Da        Isoelectric Point: 10.1206

>T194698 WP_001230709.1 NZ_CP070924:7053-7307 [Escherichia coli]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA

Download         Length: 255 bp

>T194698 NZ_CP093930:c2237971-2237867 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATAGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9136.45 Da        Isoelectric Point: 7.2775

>AT194698 WP_000151456.1 NZ_CP070924:7304-7546 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP

Download         Length: 243 bp

>AT194698 NZ_CP093930:2237774-2237812 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References