194696

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 43111..43646 Replicon plasmid p40EC-3
Accession NZ_CP070923
Organism Escherichia coli strain 40EC

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag JR909_RS24545 Protein ID WP_000222771.1
Coordinates 43111..43398 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag JR909_RS24550 Protein ID WP_001139206.1
Coordinates 43395..43646 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR909_RS24520 39976..40181 - 206 Protein_35 transposase -
JR909_RS24525 40171..40371 + 201 WP_000896262.1 DUF839 domain-containing protein -
JR909_RS24530 40618..40998 + 381 WP_001466366.1 IS66 family insertion sequence hypothetical protein -
JR909_RS24535 40995..41342 + 348 WP_000612591.1 IS66 family insertion sequence element accessory protein TnpB -
JR909_RS24540 41392..42930 + 1539 WP_197385479.1 IS66 family transposase -
JR909_RS24545 43111..43398 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR909_RS24550 43395..43646 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JR909_RS24560 45593..47410 + 1818 Protein_43 helicase -
JR909_RS24565 47444..47884 + 441 WP_009447534.1 hypothetical protein -
JR909_RS24570 47881..48129 + 249 WP_000747846.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..102703 102703
- inside IScluster/Tn - - 40618..45456 4838


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T194696 WP_000222771.1 NZ_CP070923:c43398-43111 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T194696 NZ_CP093930:c2160989-2160627 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT194696 WP_001139206.1 NZ_CP070923:c43646-43395 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT194696 NZ_CP093930:c2161156-2160986 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References