Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1988..2535 Replicon plasmid p40EC-2
Accession NZ_CP070922
Organism Escherichia coli strain 40EC

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag JR909_RS23780 Protein ID WP_000969996.1
Coordinates 2254..2535 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID W0FTF6
Locus tag JR909_RS23775 Protein ID WP_000079942.1
Coordinates 1988..2257 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR909_RS23770 46..1077 + 1032 WP_000907875.1 replication initiation protein -
JR909_RS23775 1988..2257 + 270 WP_000079942.1 hypothetical protein Antitoxin
JR909_RS23780 2254..2535 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR909_RS23785 2581..2793 + 213 Protein_3 3'-5' exonuclease -
JR909_RS23790 3052..3981 - 930 WP_000102288.1 hypothetical protein -
JR909_RS23795 4418..5605 - 1188 WP_001697863.1 IS91 family transposase -
JR909_RS23800 5605..5970 - 366 WP_000124134.1 hypothetical protein -
JR909_RS23805 6118..7410 - 1293 Protein_7 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-55 - 1..104226 104226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T194691 WP_000969996.1 NZ_CP070922:2254-2535 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T194691 NZ_CP093930:c1576148-1575903 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10282.61 Da        Isoelectric Point: 7.2057

>AT194691 WP_000079942.1 NZ_CP070922:1988-2257 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT194691 NZ_CP093930:1575569-1575934 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A140JYS5

References