194669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1323624..1324249 Replicon chromosome
Accession NZ_CP070920
Organism Escherichia coli strain 40EC

Toxin (Protein)


Gene name vapC Uniprot ID A0A2J1DF47
Locus tag JR909_RS06455 Protein ID WP_000911331.1
Coordinates 1323851..1324249 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JR909_RS06450 Protein ID WP_000450524.1
Coordinates 1323624..1323851 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR909_RS06425 1319426..1319896 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JR909_RS06430 1319896..1320468 - 573 WP_000176191.1 glycine cleavage system transcriptional repressor -
JR909_RS06435 1320614..1321492 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JR909_RS06440 1321509..1322543 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
JR909_RS06445 1322756..1323469 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JR909_RS06450 1323624..1323851 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JR909_RS06455 1323851..1324249 + 399 WP_000911331.1 tRNA(fMet)-specific endonuclease VapC Toxin
JR909_RS06460 1324396..1325259 + 864 WP_001267507.1 neutral zinc metallopeptidase -
JR909_RS06465 1325274..1327289 + 2016 WP_001543081.1 tRNA cytosine(34) acetyltransferase TmcA -
JR909_RS06470 1327363..1328061 + 699 WP_000679812.1 esterase -
JR909_RS06475 1328171..1328371 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.19 Da        Isoelectric Point: 9.2216

>T194669 WP_000911331.1 NZ_CP070920:1323851-1324249 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLVELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T194669 NZ_CP093919:c1920903-1920526 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT194669 WP_000450524.1 NZ_CP070920:1323624-1323851 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT194669 NZ_CP093919:c1921361-1920993 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCACCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J1DF47

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References