Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 42202..42803 Replicon plasmid p65COLEC-2
Accession NZ_CP070916
Organism Escherichia coli strain 65COLEC

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag JR892_RS23885 Protein ID WP_001216039.1
Coordinates 42202..42582 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag JR892_RS23890 Protein ID WP_001190711.1
Coordinates 42582..42803 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR892_RS23850 37264..38295 - 1032 WP_000067537.1 site-specific integrase -
JR892_RS23855 38303..38524 - 222 WP_000542338.1 hypothetical protein -
JR892_RS23860 39129..39338 + 210 WP_000874156.1 hypothetical protein -
JR892_RS23865 39449..40300 + 852 WP_000611661.1 hypothetical protein -
JR892_RS23870 40333..40644 - 312 WP_001351993.1 phage antirepressor Ant -
JR892_RS23875 40947..41990 - 1044 WP_069067567.1 DUF968 domain-containing protein -
JR892_RS23880 42018..42197 - 180 WP_000113018.1 hypothetical protein -
JR892_RS23885 42202..42582 - 381 WP_001216039.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JR892_RS23890 42582..42803 - 222 WP_001190711.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JR892_RS23895 43068..43765 + 698 Protein_44 IS1 family transposase -
JR892_RS23900 43782..44108 - 327 Protein_45 hypothetical protein -
JR892_RS23905 44181..45443 - 1263 WP_069067570.1 hypothetical protein -
JR892_RS23910 45745..46446 - 702 WP_000684873.1 hypothetical protein -
JR892_RS23915 46443..46991 - 549 Protein_48 metallophosphoesterase -
JR892_RS23920 47007..47704 - 698 Protein_49 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) - 1..106065 106065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13558.27 Da        Isoelectric Point: 5.1514

>T194665 WP_001216039.1 NZ_CP070916:c42582-42202 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRAALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T194665 NZ_CP093919:933279-933686 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8134.08 Da        Isoelectric Point: 4.5843

>AT194665 WP_001190711.1 NZ_CP070916:c42803-42582 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVDR

Download         Length: 222 bp

>AT194665 NZ_CP093919:933032-933298 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References