Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49179..50011 Replicon chromosome
Accession NZ_CP070914
Organism Escherichia coli strain 65COLEC

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag JR892_RS00245 Protein ID WP_000854753.1
Coordinates 49179..49553 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag JR892_RS00250 Protein ID WP_001280951.1
Coordinates 49643..50011 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR892_RS00220 44544..45467 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
JR892_RS00225 45578..46762 - 1185 WP_077492827.1 sugar efflux transporter -
JR892_RS00230 47555..48400 - 846 WP_001406222.1 DUF4942 domain-containing protein -
JR892_RS00235 48485..48682 - 198 WP_000839243.1 DUF957 domain-containing protein -
JR892_RS00240 48694..49182 - 489 WP_001549830.1 hypothetical protein -
JR892_RS00245 49179..49553 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
JR892_RS00250 49643..50011 - 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JR892_RS00255 50174..50395 - 222 WP_001405861.1 DUF987 domain-containing protein -
JR892_RS00260 50464..50940 - 477 WP_001186724.1 RadC family protein -
JR892_RS00265 50956..51129 - 174 Protein_52 antirestriction protein -
JR892_RS00270 51092..52185 + 1094 WP_088568459.1 IS3 family transposase -
JR892_RS00275 53124..54119 - 996 WP_000157595.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T194642 WP_000854753.1 NZ_CP070914:c49553-49179 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T194642 NZ_CP093913:942149-942415 [Aggregatibacter actinomycetemcomitans]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCATTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT194642 WP_001280951.1 NZ_CP070914:c50011-49643 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT194642 NZ_CP093913:941865-942137 [Aggregatibacter actinomycetemcomitans]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATGCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References