Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 109011..109546 Replicon plasmid p88COLEC-1
Accession NZ_CP070907
Organism Escherichia coli strain 88COLEC

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag JR901_RS23765 Protein ID WP_000222771.1
Coordinates 109259..109546 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag JR901_RS23760 Protein ID WP_001139206.1
Coordinates 109011..109262 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR901_RS23740 104528..104776 - 249 WP_000747846.1 hypothetical protein -
JR901_RS23745 104773..105213 - 441 WP_023352064.1 hypothetical protein -
JR901_RS23750 105247..107064 - 1818 Protein_123 helicase -
JR901_RS23755 107201..108429 + 1229 WP_153449191.1 IS3 family transposase -
JR901_RS23760 109011..109262 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JR901_RS23765 109259..109546 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JR901_RS23770 109836..110036 - 201 WP_000896262.1 DUF839 domain-containing protein -
JR901_RS23775 110026..110231 + 206 Protein_128 transposase -
JR901_RS23780 110406..113921 - 3516 WP_072649717.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaTEM-1B / sul3 / ant(3'')-Ia / floR / tet(A) - 1..142545 142545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T194640 WP_000222771.1 NZ_CP070907:109259-109546 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T194640 NZ_CP093913:c402722-402471 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTTGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGGGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT194640 WP_001139206.1 NZ_CP070907:109011-109262 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT194640 NZ_CP093913:c402474-402220 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGAGCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References