Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 85759..86360 Replicon plasmid p88COLEC-1
Accession NZ_CP070907
Organism Escherichia coli strain 88COLEC

Toxin (Protein)


Gene name doc Uniprot ID U9ZW91
Locus tag JR901_RS23645 Protein ID WP_001216033.1
Coordinates 85980..86360 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag JR901_RS23640 Protein ID WP_001190712.1
Coordinates 85759..85980 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR901_RS23610 81370..81548 + 179 Protein_95 hypothetical protein -
JR901_RS23615 81882..82763 + 882 WP_000628760.1 hypothetical protein -
JR901_RS23620 82760..83122 + 363 WP_001261543.1 hypothetical protein -
JR901_RS23625 84181..84537 - 357 WP_001062545.1 hypothetical protein -
JR901_RS23630 84538..84936 - 399 WP_001648136.1 hypothetical protein -
JR901_RS23635 85297..85686 + 390 WP_000506724.1 DNA repair protein -
JR901_RS23640 85759..85980 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JR901_RS23645 85980..86360 + 381 WP_001216033.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JR901_RS23650 86365..86544 + 180 WP_024262170.1 hypothetical protein -
JR901_RS23655 86572..87615 + 1044 WP_072649708.1 DUF968 domain-containing protein -
JR901_RS23660 87704..88156 + 453 WP_001326849.1 late promoter-activating protein -
JR901_RS23665 88242..89435 + 1194 WP_205899144.1 terminase -
JR901_RS23670 90893..91305 + 413 Protein_107 phage antirepressor KilAC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaTEM-1B / sul3 / ant(3'')-Ia / floR / tet(A) - 1..142545 142545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13571.31 Da        Isoelectric Point: 5.6343

>T194639 WP_001216033.1 NZ_CP070907:85980-86360 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVAATLRRLYGSAE

Download         Length: 381 bp

>T194639 NZ_CP093913:c402474-402220 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGAGCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT194639 WP_001190712.1 NZ_CP070907:85759-85980 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT194639 NZ_CP093913:c402722-402471 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTTGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGGGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZW91

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References