Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1861152..1861983 Replicon chromosome
Accession NZ_CP070906
Organism Escherichia coli strain 88COLEC

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3K2V2C4
Locus tag JR901_RS08765 Protein ID WP_001510972.1
Coordinates 1861152..1861526 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JR901_RS08770 Protein ID WP_001285585.1
Coordinates 1861615..1861983 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR901_RS08725 1856548..1857714 + 1167 WP_205899118.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JR901_RS08730 1857833..1858306 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
JR901_RS08735 1858504..1859562 + 1059 WP_001200891.1 FUSC family protein -
JR901_RS08740 1859734..1860063 + 330 WP_000450409.1 DUF496 family protein -
JR901_RS08745 1860164..1860346 - 183 WP_001016348.1 hypothetical protein -
JR901_RS08750 1860418..1860546 + 129 Protein_1710 transposase domain-containing protein -
JR901_RS08755 1860835..1860948 - 114 WP_032154230.1 DUF957 domain-containing protein -
JR901_RS08760 1860961..1861155 - 195 WP_000988600.1 hypothetical protein -
JR901_RS08765 1861152..1861526 - 375 WP_001510972.1 type IV toxin-antitoxin system toxin CbtA Toxin
JR901_RS08770 1861615..1861983 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JR901_RS08775 1862057..1862278 - 222 WP_000692323.1 DUF987 domain-containing protein -
JR901_RS08780 1862341..1862817 - 477 WP_001186773.1 RadC family protein -
JR901_RS08785 1862833..1863312 - 480 WP_000860076.1 antirestriction protein -
JR901_RS08790 1863394..1864212 - 819 WP_001234629.1 DUF945 domain-containing protein -
JR901_RS08795 1864312..1864545 - 234 WP_001119724.1 DUF905 family protein -
JR901_RS08800 1864624..1865079 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13924.98 Da        Isoelectric Point: 7.8522

>T194621 WP_001510972.1 NZ_CP070906:c1861526-1861152 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T194621 NZ_CP093911:c1484632-1484336 [Aggregatibacter actinomycetemcomitans]
ATGGGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTACGCTTCTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT194621 WP_001285585.1 NZ_CP070906:c1861983-1861615 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT194621 NZ_CP093911:c1484928-1484617 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGAGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGGGTGAACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2V2C4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References