Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 928433..929087 Replicon chromosome
Accession NZ_CP070906
Organism Escherichia coli strain 88COLEC

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag JR901_RS04460 Protein ID WP_205899095.1
Coordinates 928680..929087 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JR901_RS04455 Protein ID WP_000354046.1
Coordinates 928433..928699 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR901_RS04435 924521..925954 - 1434 WP_021557183.1 6-phospho-beta-glucosidase BglA -
JR901_RS04440 925999..926310 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
JR901_RS04445 926474..927133 + 660 WP_000250274.1 hemolysin III family protein -
JR901_RS04450 927210..928190 - 981 WP_001625883.1 tRNA-modifying protein YgfZ -
JR901_RS04455 928433..928699 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JR901_RS04460 928680..929087 + 408 WP_205899095.1 protein YgfX Toxin
JR901_RS04465 929127..929648 - 522 WP_001055874.1 flavodoxin FldB -
JR901_RS04470 929760..930656 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JR901_RS04475 930681..931391 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JR901_RS04480 931397..933130 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15988.93 Da        Isoelectric Point: 11.2669

>T194618 WP_205899095.1 NZ_CP070906:928680-929087 [Escherichia coli]
VVLWQSDLLVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T194618 NZ_CP093911:1323929-1324111 [Aggregatibacter actinomycetemcomitans]
ATGAAATACAGTGAATTCTTGCGATACTTGCTTGAGCAAGGCTGCAAAGTCGAAGCAACCAAGCGCGGAAGTCATCGCAA
GGTAACGTTGAATGAGTGCCAAACTGTCTTTCCCTACCATGGTAGTAAAGAAATCGGTACCGGCTTAGTTCACAAAATCA
AAAAAGACTTAAACTTAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT194618 WP_000354046.1 NZ_CP070906:928433-928699 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194618 NZ_CP093911:1324163-1324582 [Aggregatibacter actinomycetemcomitans]
ATGTTACGCTACCCTGTTGAAATCACCCCGGATGATAACGGTACATTCCTTGTCACTTGCCCCGATATTCCCGAAATGGC
AAGTGTAGGTGAAGATATTGAAAGCGCACTACTTGAAGCGGAAGAAGGTTTAGAAACCGCCCTCGAATTTTATTTTGATG
ATAAACGCCCAATTCCAATGCCAAGCCAGCCAAAAGATGGGCAATATACGGTTCCGCTTTCCTTATTGCGTTCACTAAAA
GTCTTCTTACTCAATGAAATGCTCGCACAAGGTGTGCGAAAAGCTGAAATGGCGCGCCGTCTTGATGTTCACATGCCGCA
AGTCGATCGCTTATTAGATTTTCGCCACCCATCCAAAATTGATTTTGTTGAAAAAGCCTTTAAAAAATTAGGGCGCGAAA
TTAATTTATCGGTTCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References