Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 295639..296270 Replicon chromosome
Accession NZ_CP070906
Organism Escherichia coli strain 88COLEC

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M1UJK7
Locus tag JR901_RS01265 Protein ID WP_001259382.1
Coordinates 295639..295914 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag JR901_RS01270 Protein ID WP_000593555.1
Coordinates 295911..296270 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR901_RS01250 290772..291710 + 939 Protein_247 HlyD family efflux transporter periplasmic adaptor subunit -
JR901_RS01255 291707..294442 + 2736 WP_000149130.1 ribosome-associated ATPase/putative transporter RbbA -
JR901_RS01260 294442..295566 + 1125 WP_021557290.1 ABC transporter permease -
JR901_RS01265 295639..295914 + 276 WP_001259382.1 type II toxin-antitoxin system HicA family toxin Toxin
JR901_RS01270 295911..296270 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JR901_RS01275 296320..297180 - 861 WP_021557289.1 class II aldolase -
JR901_RS01280 297212..297481 - 270 WP_000933060.1 HPr family phosphocarrier protein -
JR901_RS01285 297471..298979 - 1509 WP_021557288.1 xylulose kinase -
JR901_RS01290 298972..300330 - 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
JR901_RS01295 300407..300688 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
JR901_RS01300 300685..301158 - 474 WP_001161650.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 290004..290708 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.91 Da        Isoelectric Point: 10.7076

>T194615 WP_001259382.1 NZ_CP070906:295639-295914 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T194615 NZ_CP093910:1911070-1911360 [Aggregatibacter actinomycetemcomitans]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGGAAAAGTTAGGTGACACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCCGGCGACAAATTAAAAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAAATGCATACAAAAATGCAGAATTCAGACAAGCCCGGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT194615 WP_000593555.1 NZ_CP070906:295911-296270 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT194615 NZ_CP093910:1910826-1911080 [Aggregatibacter actinomycetemcomitans]
ATGGCAATACATCAAATTTTGACACAACAAGCCGCAAGCATTACCGATTTAAAACGGGACCCAATGGGCATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCGTAACCAACCGGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATCGCTGAAGAGCGTCTGGCGACCCTTGATCCGATTGAGGTAAGC
CTTGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1UJK7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References