Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2487716..2488354 Replicon chromosome
Accession NZ_CP070902
Organism Escherichia coli strain 99COLEC

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JR895_RS11945 Protein ID WP_000813794.1
Coordinates 2488178..2488354 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JR895_RS11940 Protein ID WP_001270286.1
Coordinates 2487716..2488132 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR895_RS11920 2482868..2483809 - 942 WP_001251319.1 ABC transporter permease -
JR895_RS11925 2483810..2484823 - 1014 WP_000220393.1 ABC transporter ATP-binding protein -
JR895_RS11930 2484841..2485986 - 1146 WP_000047429.1 ABC transporter substrate-binding protein -
JR895_RS11935 2486228..2487637 - 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
JR895_RS11940 2487716..2488132 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JR895_RS11945 2488178..2488354 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JR895_RS11950 2488576..2488806 + 231 WP_000494244.1 YncJ family protein -
JR895_RS11955 2488898..2490859 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JR895_RS11960 2490932..2491468 - 537 WP_001569804.1 DNA-binding transcriptional regulator SutR -
JR895_RS11965 2491521..2492735 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T194610 WP_000813794.1 NZ_CP070902:c2488354-2488178 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T194610 NZ_CP093910:c1283109-1282927 [Aggregatibacter actinomycetemcomitans]
ATGAAATACAGTGAATTCTTGCGATACTTGCTTGAGCAAGGCTGCAAAGTCGAAGCAACCAAGCGCGGAAGTCATCGCAA
GGTAACGTTGAATGAGTGCCAAACTGTCTTTCCCTACCATGGTAGTAAAGAAATCGGTACCGGCTTAGTTCACAAAATCA
AAAAAGACTTAAACTTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT194610 WP_001270286.1 NZ_CP070902:c2488132-2487716 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT194610 NZ_CP093910:c1282875-1282456 [Aggregatibacter actinomycetemcomitans]
ATGTTACGCTACCCTGTTGAAATCACCCCGGATGATAACGGTACATTCCTTGTCACTTGCCCCGATATTCCCGAAATGGC
AAGTGTAGGTGAAGATATTGAAAGCGCACTACTTGAAGCGGAAGAAGGTTTAGAAACCGCCCTCGAATTTTATTTTGATG
ATAAACGCCCAATTCCAATGCCAAGCCAGCCAAAAGATGGGCAATATACGGTTCCGCTTTCCTTATTGCGTTCACTAAAA
GTCTTCTTACTCAATGAAATGCTCGCACAAGGTGTGCGAAAAGCTGAAATGGCGCGCCGTCTTGATGTTCACATGCCGCA
AGTCGATCGCTTATTAGATTTTCGCCACCCATCCAAAATTGATTTTGTTGAAAAAGCCTTTAAAAAATTAGGGCGCGAAA
TTAATTTATCGGTTCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References