Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 48918..49753 Replicon chromosome
Accession NZ_CP070902
Organism Escherichia coli strain 99COLEC

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag JR895_RS00250 Protein ID WP_000854821.1
Coordinates 48918..49295 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TIK7
Locus tag JR895_RS00255 Protein ID WP_001285605.1
Coordinates 49385..49753 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR895_RS00225 44559..45482 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
JR895_RS00230 45593..46777 - 1185 WP_001172876.1 sugar efflux transporter -
JR895_RS00235 47572..48414 - 843 WP_001696593.1 DUF4942 domain-containing protein -
JR895_RS00240 48499..48696 - 198 WP_086795284.1 DUF957 domain-containing protein -
JR895_RS00245 48772..48921 - 150 Protein_48 hypothetical protein -
JR895_RS00250 48918..49295 - 378 WP_000854821.1 type IV toxin-antitoxin system toxin CbtA Toxin
JR895_RS00255 49385..49753 - 369 WP_001285605.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JR895_RS00260 49833..50054 - 222 Protein_51 DUF987 domain-containing protein -
JR895_RS00265 50141..50617 - 477 WP_004025728.1 RadC family protein -
JR895_RS00270 50633..50803 - 171 Protein_53 antirestriction protein -
JR895_RS00275 50867..51097 - 231 Protein_54 WYL domain-containing protein -
JR895_RS00280 51351..51524 + 174 WP_153274857.1 hypothetical protein -
JR895_RS00285 51938..52372 + 435 WP_086586397.1 H-NS histone family protein -
JR895_RS00290 52789..53358 - 570 WP_025670550.1 hypothetical protein -
JR895_RS00295 53458..54690 - 1233 WP_086586395.1 dNTP triphosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T194594 WP_000854821.1 NZ_CP070902:c49295-48918 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T194594 NZ_CP093856:c3249819-3249286 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCCAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.48 Da        Isoelectric Point: 6.0601

>AT194594 WP_001285605.1 NZ_CP070902:c49753-49385 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT194594 NZ_CP093856:c3250096-3249830 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2V3N6

References