Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 22250..23160 Replicon plasmid pJNQH116-1
Accession NZ_CP070899
Organism Klebsiella pneumoniae strain JNQH116

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag JYA99_RS25440 Protein ID WP_004026354.1
Coordinates 22690..23160 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag JYA99_RS25435 Protein ID WP_004026357.1
Coordinates 22250..22693 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA99_RS25405 17268..17789 + 522 WP_004213635.1 sigma-70 family RNA polymerase sigma factor -
JYA99_RS25410 17786..18739 + 954 Protein_18 fec operon regulator FecR -
JYA99_RS25415 18826..20952 + 2127 WP_004213640.1 TonB-dependent receptor family protein -
JYA99_RS25420 21027..21182 + 156 WP_004213642.1 hypothetical protein -
JYA99_RS25425 21327..21548 + 222 WP_004213643.1 DUF2188 domain-containing protein -
JYA99_RS25430 21646..22149 + 504 Protein_22 DUF4113 domain-containing protein -
JYA99_RS25435 22250..22693 + 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
JYA99_RS25440 22690..23160 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
JYA99_RS25445 23785..24482 + 698 Protein_25 IS1 family transposase -
JYA99_RS25450 25868..26817 - 950 Protein_26 DUF1173 family protein -
JYA99_RS25455 26995..27489 + 495 WP_004212794.1 thermonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA / pla 1..225276 225276
- flank IS/Tn - - 23979..24482 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T194590 WP_004026354.1 NZ_CP070899:22690-23160 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T194590 NZ_CP093856:227128-227230 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT194590 WP_004026357.1 NZ_CP070899:22250-22693 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT194590 NZ_CP093856:c227237-227092 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References