Detailed information of TA system TA194571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 3597664..3598186
• Replicon: chromosome
• Accession: NZ_CP070896
• Organism: Hungatella xylanolytica strain ASCUSBR21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JWH23_RS19945
• Protein ID: WP_277405914.1
• Coordinates: 3597923..3598186 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JWH23_RS19940
• Protein ID: WP_277405913.1
• Coordinates: 3597664..3597930 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JWH23_RS19920	3593802..3594236	+	435	WP_117417290.1	50S ribosomal protein L13	-
JWH23_RS19925	3594265..3594657	+	393	WP_104439428.1	30S ribosomal protein S9	-
JWH23_RS19930	3595191..3596825	+	1635	WP_277405912.1	methionine--tRNA ligase	-
JWH23_RS19935	3596827..3597380	+	554	Protein_3918	GNAT family N-acetyltransferase	-
JWH23_RS19940	3597664..3597930	+	267	WP_277405913.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JWH23_RS19945	3597923..3598186	+	264	WP_277405914.1	Txe/YoeB family addiction module toxin	Toxin
JWH23_RS19950	3598363..3599673	+	1311	WP_277405915.1	ABC transporter ATP-binding protein	-
JWH23_RS19955	3599670..3600047	+	378	WP_277405916.1	ATP-binding cassette domain-containing protein	-
JWH23_RS19960	3600172..3600708	+	537	WP_277405917.1	DUF6323 family protein	-
JWH23_RS19965	3600747..3601769	+	1023	WP_277405918.1	transglutaminase domain-containing protein	-
JWH23_RS19970	3601782..3602684	-	903	WP_277405919.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10391.74 Da
• Isoelectric Point: 8.8169

>T194571 WP_277405914.1 NZ_CP070896:3597923-3598186 [Hungatella xylanolytica]
MNKVFTKNGWDDYIYWQTEDRKILRKINHLIEDIARNGNEGVGKPEALSGNLAGFWNRRINDKDRLIYKIDNENIYILAC
RYHYGDK

Nucleotide

• Length: 264 bp

>T194571 NZ_CP093853:c227159-226875 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACCATTTAACCAAACACAGAAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10322.65 Da
• Isoelectric Point: 4.2457

>AT194571 WP_277405913.1 NZ_CP070896:3597664-3597930 [Hungatella xylanolytica]
MLAVNYTTLRDKMKTYMDKITDDYETLIVTRKDNKNVVMLSEESYNNMMENIYVMGNKSNYDWLIQSKAQLENGMVSTHD
LPEVEADE

Nucleotide

• Length: 267 bp

>AT194571 NZ_CP093853:c227397-227149 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA