Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4801048..4801564 Replicon chromosome
Accession NZ_CP070890
Organism Klebsiella pneumoniae strain KP-135LU

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag HZC98_RS23440 Protein ID WP_009486548.1
Coordinates 4801048..4801332 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HZC98_RS23445 Protein ID WP_002886901.1
Coordinates 4801322..4801564 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC98_RS23415 (4796465) 4796465..4796728 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
HZC98_RS23420 (4796858) 4796858..4797031 + 174 WP_032433782.1 hypothetical protein -
HZC98_RS23425 (4797034) 4797034..4797777 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HZC98_RS23430 (4798134) 4798134..4800272 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HZC98_RS23435 (4800580) 4800580..4801044 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HZC98_RS23440 (4801048) 4801048..4801332 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZC98_RS23445 (4801322) 4801322..4801564 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HZC98_RS23450 (4801642) 4801642..4803552 - 1911 WP_009486549.1 PRD domain-containing protein -
HZC98_RS23455 (4803575) 4803575..4804729 - 1155 WP_002886900.1 lactonase family protein -
HZC98_RS23460 (4804796) 4804796..4805536 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T194564 WP_009486548.1 NZ_CP070890:c4801332-4801048 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T194564 NZ_CP093852:c5361357-5361255 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT194564 WP_002886901.1 NZ_CP070890:c4801564-4801322 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT194564 NZ_CP093852:5361248-5361393 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References