Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4063635..4064254 Replicon chromosome
Accession NZ_CP070890
Organism Klebsiella pneumoniae strain KP-135LU

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HZC98_RS19980 Protein ID WP_002892050.1
Coordinates 4064036..4064254 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HZC98_RS19975 Protein ID WP_002892066.1
Coordinates 4063635..4064009 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC98_RS19965 (4058787) 4058787..4059980 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZC98_RS19970 (4060003) 4060003..4063149 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HZC98_RS19975 (4063635) 4063635..4064009 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HZC98_RS19980 (4064036) 4064036..4064254 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HZC98_RS19985 (4064417) 4064417..4064983 + 567 WP_002892030.1 maltose O-acetyltransferase -
HZC98_RS19990 (4064955) 4064955..4065095 - 141 WP_004147370.1 hypothetical protein -
HZC98_RS19995 (4065116) 4065116..4065586 + 471 WP_020802585.1 YlaC family protein -
HZC98_RS20000 (4065561) 4065561..4067012 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
HZC98_RS20005 (4067113) 4067113..4067811 + 699 WP_023287311.1 GNAT family protein -
HZC98_RS20010 (4067808) 4067808..4067948 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HZC98_RS20015 (4067948) 4067948..4068211 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T194562 WP_002892050.1 NZ_CP070890:4064036-4064254 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T194562 NZ_CP093852:4883295-4883705 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGAAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT194562 WP_002892066.1 NZ_CP070890:4063635-4064009 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT194562 NZ_CP093852:4883048-4883314 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References