Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1452955..1453598 Replicon chromosome
Accession NZ_CP070890
Organism Klebsiella pneumoniae strain KP-135LU

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag HZC98_RS07165 Protein ID WP_032433387.1
Coordinates 1453182..1453598 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag HZC98_RS07160 Protein ID WP_001261276.1
Coordinates 1452955..1453185 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC98_RS07145 (1447977) 1447977..1449064 + 1088 Protein_1397 transcriptional repressor PifC -
HZC98_RS07150 (1449067) 1449067..1451307 + 2241 WP_045326788.1 P-loop NTPase fold protein -
HZC98_RS07155 (1451835) 1451835..1452650 - 816 WP_032433388.1 hypothetical protein -
HZC98_RS07160 (1452955) 1452955..1453185 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HZC98_RS07165 (1453182) 1453182..1453598 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
HZC98_RS07170 (1453754) 1453754..1454734 + 981 WP_032433385.1 hypothetical protein -
HZC98_RS07175 (1454929) 1454929..1456500 - 1572 WP_032433383.1 AAA family ATPase -
HZC98_RS07180 (1456819) 1456819..1457067 + 249 WP_032433382.1 hypothetical protein -
HZC98_RS07185 (1457126) 1457126..1457644 + 519 WP_045326794.1 hypothetical protein -
HZC98_RS07190 (1457675) 1457675..1458166 + 492 WP_032433378.1 hypothetical protein -
HZC98_RS07195 (1458226) 1458226..1458429 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1437591..1483608 46017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T194551 WP_032433387.1 NZ_CP070890:1453182-1453598 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T194551 NZ_CP093550:78544-78693 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT194551 WP_001261276.1 NZ_CP070890:1452955-1453185 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT194551 NZ_CP093550:c78499-78440 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References