Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835075..835732 Replicon chromosome
Accession NZ_CP070890
Organism Klebsiella pneumoniae strain KP-135LU

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HZC98_RS04190 Protein ID WP_002916310.1
Coordinates 835322..835732 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HZC98_RS04185 Protein ID WP_002916312.1
Coordinates 835075..835341 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZC98_RS04160 (830231) 830231..831664 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
HZC98_RS04165 (831783) 831783..832511 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HZC98_RS04170 (832561) 832561..832872 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HZC98_RS04175 (833036) 833036..833695 + 660 WP_002916317.1 hemolysin III family protein -
HZC98_RS04180 (833846) 833846..834829 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HZC98_RS04185 (835075) 835075..835341 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HZC98_RS04190 (835322) 835322..835732 + 411 WP_002916310.1 protein YgfX Toxin
HZC98_RS04195 (835739) 835739..836260 - 522 WP_004144730.1 flavodoxin FldB -
HZC98_RS04200 (836361) 836361..837257 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HZC98_RS04205 (837280) 837280..837993 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZC98_RS04210 (837999) 837999..839732 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T194550 WP_002916310.1 NZ_CP070890:835322-835732 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T194550 NZ_CP093550:2041-2319 [Escherichia coli]
ATGGAGATATTCTGGACCATACTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTATATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT194550 WP_002916312.1 NZ_CP070890:835075-835341 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194550 NZ_CP093550:1772-2041 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACTTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCCCATGATATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATAAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References