Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 85340..85962 Replicon plasmid plas1
Accession NZ_CP070867
Organism Acinetobacter johnsonii strain XY27

Toxin (Protein)


Gene name vapC Uniprot ID A0A7H8SKU4
Locus tag JW980_RS17530 Protein ID WP_063454755.1
Coordinates 85567..85962 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R9B9I8
Locus tag JW980_RS17525 Protein ID WP_000401521.1
Coordinates 85340..85570 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW980_RS17495 81036..81371 + 336 WP_035363642.1 hypothetical protein -
JW980_RS17500 81421..81600 + 180 WP_016658770.1 hypothetical protein -
JW980_RS17505 81597..81983 + 387 WP_004769969.1 type II toxin-antitoxin system death-on-curing family toxin -
JW980_RS17510 81985..82536 - 552 WP_016658769.1 macro domain-containing protein -
JW980_RS17515 82542..83225 - 684 WP_016658768.1 hypothetical protein -
JW980_RS17520 83435..84760 + 1326 Protein_96 ISNCY family transposase -
JW980_RS17525 85340..85570 + 231 WP_000401521.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JW980_RS17530 85567..85962 + 396 WP_063454755.1 type II toxin-antitoxin system VapC family toxin Toxin
JW980_RS17535 86123..86554 + 432 WP_063454756.1 hypothetical protein -
JW980_RS17540 86676..87275 - 600 Protein_100 ISNCY family transposase -
JW980_RS17545 87338..88470 - 1133 Protein_101 IS3 family transposase -
JW980_RS17550 88555..89295 - 741 Protein_102 ISNCY family transposase -
JW980_RS17555 89503..90300 + 798 Protein_103 IS5 family transposase -
JW980_RS17560 90319..90456 + 138 WP_004637095.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..149408 149408
- inside IScluster/Tn - - 61437..101593 40156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14897.23 Da        Isoelectric Point: 7.1633

>T194522 WP_063454755.1 NZ_CP070867:85567-85962 [Acinetobacter johnsonii]
MIYLLDTNICIYVINNKPQQVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKKALNKFLSPLEILPYDEQAIWHYA
KLRQNLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T194522 NZ_CP093548:c538685-538536 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8759.04 Da        Isoelectric Point: 4.7708

>AT194522 WP_000401521.1 NZ_CP070867:85340-85570 [Acinetobacter johnsonii]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEVGFQLERADQGEQLREEFR

Download         Length: 231 bp

>AT194522 NZ_CP093548:538314-538492 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8SKU4

Antitoxin

Source ID Structure
AlphaFold DB A0A2N6V6E6

References