Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 4231383..4232179 Replicon chromosome
Accession NZ_CP070865
Organism Shewanella putrefaciens strain XY07

Toxin (Protein)


Gene name - Uniprot ID A0A6N3J9I8
Locus tag JW975_RS18760 Protein ID WP_011791158.1
Coordinates 4231383..4231913 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6N3J9J2
Locus tag JW975_RS18765 Protein ID WP_011791159.1
Coordinates 4231910..4232179 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW975_RS18740 4227923..4228690 - 768 WP_011791154.1 class I SAM-dependent methyltransferase -
JW975_RS18745 4228965..4229738 + 774 WP_011791155.1 hypothetical protein -
JW975_RS18750 4230013..4230483 + 471 WP_011791156.1 hypothetical protein -
JW975_RS18755 4230546..4230974 + 429 Protein_3624 hypothetical protein -
JW975_RS18760 4231383..4231913 - 531 WP_011791158.1 GNAT family N-acetyltransferase Toxin
JW975_RS18765 4231910..4232179 - 270 WP_011791159.1 DUF1778 domain-containing protein Antitoxin
JW975_RS18770 4232556..4233110 - 555 WP_025007978.1 transglycosylase domain-containing protein -
JW975_RS18775 4233486..4233710 - 225 WP_025007977.1 hypothetical protein -
JW975_RS18780 4234066..4234758 - 693 WP_025007976.1 hypothetical protein -
JW975_RS18785 4235266..4235649 - 384 WP_011791162.1 GIY-YIG nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19795.16 Da        Isoelectric Point: 8.3330

>T194520 WP_011791158.1 NZ_CP070865:c4231913-4231383 [Shewanella putrefaciens]
VSYSKIFKELDKSLHDRVSFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAAMPLPNQKYPICSFYTIAPSSICRDTLPQ
AIGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTDQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Download         Length: 531 bp

>T194520 NZ_CP093548:c382589-382482 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9859.32 Da        Isoelectric Point: 4.7037

>AT194520 WP_011791159.1 NZ_CP070865:c4232179-4231910 [Shewanella putrefaciens]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATQVIAEHESVTVKADVFDQFIMACDEAKVPNKALREAA
AFTKNGEFK

Download         Length: 270 bp

>AT194520 NZ_CP093548:382637-382703 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3J9I8

Antitoxin

Source ID Structure
AlphaFold DB A0A6N3J9J2

References