Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 77200..77768 Replicon plasmid unnamed5
Accession NZ_CP070614
Organism Rhodococcus sp. R79

Toxin (Protein)


Gene name relE Uniprot ID A0A848PSC1
Locus tag JWS13_RS00325 Protein ID WP_037205898.1
Coordinates 77520..77768 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID K8XBN5
Locus tag JWS13_RS00320 Protein ID WP_005261720.1
Coordinates 77200..77490 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JWS13_RS00310 72323..74680 + 2358 WP_005261718.1 helicase-associated domain-containing protein -
JWS13_RS00315 74990..76873 + 1884 WP_037205864.1 RNB domain-containing ribonuclease -
JWS13_RS00320 77200..77490 + 291 WP_005261720.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JWS13_RS00325 77520..77768 + 249 WP_037205898.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JWS13_RS00330 77813..78118 + 306 WP_037205900.1 hypothetical protein -
JWS13_RS00335 78239..78709 + 471 Protein_66 hypothetical protein -
JWS13_RS00340 79094..79690 - 597 WP_080606244.1 helicase associated domain-containing protein -
JWS13_RS00345 79882..80117 + 236 Protein_68 ACP phosphodiesterase -
JWS13_RS00350 80420..80929 + 510 WP_169693811.1 DUF3052 domain-containing protein -
JWS13_RS00355 81475..82698 + 1224 WP_051055435.1 NarK/NasA family nitrate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..468864 468864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(26-80)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8968.27 Da        Isoelectric Point: 9.8455

>T194510 WP_037205898.1 NZ_CP070614:77520-77768 [Rhodococcus sp. R79]
MAWSAARALATSVPEKVATAVYEFVTGPLLDNPRRVGKPLDPPLAPAYSARRGTYRVLYLINDGNRMVEVTAIAHRADAY
HS

Download         Length: 249 bp

>T194510 NZ_CP093536:c52805-52578 [Ralstonia pseudosolanacearum]
GTGCGCATCGACCGCCTGCAGATGGGCCACCCGGGCGACATGAAAGCGGTCCGTGACGGCATCCGTGAGCTGCGGATCGA
TCATGGGCCGGGCGACCGCTTGTACTTCGTGCGGCATGGCGTGGTCCTGATCGTACTGCTCTGCGGCGGCGACAAGTCGA
CGCAGGAAACCGATATCCGTCGCGCAATTGACCTGTCCCGCCGTCTCGACGTGGACGACATGGAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10364.54 Da        Isoelectric Point: 4.4315

>AT194510 WP_005261720.1 NZ_CP070614:77200-77490 [Rhodococcus sp. R79]
MYMTTLPVADARAQLSRLVDEAEHTHERFEITRNGHRAAVLLGADDYDALRETIAVLSDTDLLAAHLAGRAEVEGGDVVD
AAELARLMRGAFSSGE

Download         Length: 291 bp

>AT194510 NZ_CP093536:c52581-52276 [Ralstonia pseudosolanacearum]
ATGACGATGGCCCAACGCACCATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTCCGGACCGAAGCGGACATCGCCGC
CTACCTCGACGCCTGCCTGGAAGAAGCCGGAGATGACCCCGCCTTCATCACGCATGCGCTGGGCGTGGTCGCGCGCTCGC
GCGGCATGACGCAGCTCGCCCGCGAGACCGGGATGACCCGTGAAGGGCTGTACAAGGCGCTTTCCGAGGGCGGCAATCCG
AGCTTTGCGACCGTGCTGAAGGTCATCCGGGCGCTCGGCATCCGGCTGCACGCCGTGCCGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A848PSC1

Antitoxin

Source ID Structure
AlphaFold DB K8XBN5

References