Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3472975..3473632 Replicon chromosome
Accession NZ_CP070602
Organism Klebsiella pneumoniae strain KPA9853

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JW307_RS17880 Protein ID WP_002916310.1
Coordinates 3473222..3473632 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JW307_RS17875 Protein ID WP_002916312.1
Coordinates 3472975..3473241 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW307_RS17850 3468131..3469564 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
JW307_RS17855 3469683..3470411 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JW307_RS17860 3470461..3470772 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JW307_RS17865 3470936..3471595 + 660 WP_002916317.1 hemolysin III family protein -
JW307_RS17870 3471746..3472729 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JW307_RS17875 3472975..3473241 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JW307_RS17880 3473222..3473632 + 411 WP_002916310.1 protein YgfX Toxin
JW307_RS17885 3473639..3474160 - 522 WP_004144730.1 flavodoxin FldB -
JW307_RS17890 3474261..3475157 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JW307_RS17895 3475180..3475893 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JW307_RS17900 3475899..3477632 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T194495 WP_002916310.1 NZ_CP070602:3473222-3473632 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T194495 NZ_CP093527:c2448243-2448136 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT194495 WP_002916312.1 NZ_CP070602:3472975-3473241 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194495 NZ_CP093527:2448059-2448119 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References