194487

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 242..716 Replicon plasmid pA9853_1
Accession NZ_CP070601
Organism Klebsiella pneumoniae strain KPA9853

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag JW307_RS01010 Protein ID WP_004197762.1
Coordinates 242..508 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag JW307_RS01015 Protein ID WP_000879771.1
Coordinates 492..716 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW307_RS01010 242..508 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW307_RS01015 492..716 - 225 WP_000879771.1 TraY domain-containing protein Antitoxin
JW307_RS01020 1383..1595 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
JW307_RS01025 1602..2111 - 510 WP_032433972.1 MbeB family mobilization protein -
JW307_RS01030 2086..2850 - 765 Protein_5 relaxase/mobilization nuclease domain-containing protein -
JW307_RS01035 2789..3133 - 345 WP_004197764.1 MobC family plasmid mobilization relaxosome protein -
JW307_RS01040 3123..3299 - 177 WP_165764108.1 hypothetical protein -
JW307_RS01045 4402..4783 + 382 Protein_8 hypothetical protein -
JW307_RS01050 4809..5354 + 546 WP_032433973.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5598 5598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T194487 WP_004197762.1 NZ_CP070601:c508-242 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T194487 NZ_CP093527:509718-509822 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT194487 WP_000879771.1 NZ_CP070601:c716-492 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT194487 NZ_CP093527:c509981-509817 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References