Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4789632..4790148 Replicon chromosome
Accession NZ_CP070598
Organism Klebsiella pneumoniae strain KPA4411

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JW306_RS25670 Protein ID WP_002886902.1
Coordinates 4789632..4789916 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JW306_RS25675 Protein ID WP_002886901.1
Coordinates 4789906..4790148 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW306_RS25645 4785116..4785424 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
JW306_RS25650 4785509..4785682 + 174 WP_002886906.1 hypothetical protein -
JW306_RS25655 4785685..4786428 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JW306_RS25660 4786785..4788923 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
JW306_RS25665 4789164..4789628 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JW306_RS25670 4789632..4789916 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW306_RS25675 4789906..4790148 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JW306_RS25680 4790226..4792136 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JW306_RS25685 4792159..4793313 - 1155 WP_002886900.1 lactonase family protein -
JW306_RS25690 4793379..4794119 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T194483 WP_002886902.1 NZ_CP070598:c4789916-4789632 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T194483 NZ_CP093501:5015703-5016080 [Klebsiella pneumoniae]
ATGAAAACATTACCCGACACACACGAACGGGAGGCGTCACGCTGCTCGTCTCCTGTGACAATCTGGCAGACACTCCTGGC
CCGGCTGCTGGGCCAGCATTACAGCCTCACGCTGAATGACACGCCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAGTACGCGCTGGTACGTACCGACCAGCCGGGATTC
GGCACCTGTGCCCATTCGCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGTTGACCCGCAG
CAACTACAGAACGGTGAACGACATTATCCGGGGTAAAGATGCGGAGGCAAAACAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT194483 WP_002886901.1 NZ_CP070598:c4790148-4789906 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT194483 NZ_CP093501:5015279-5015656 [Klebsiella pneumoniae]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAGGGTAACCGGTTGCATTACCTTGCAGATCGCGCAGGTATAAGAGGTCAGT
TCAGCAACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGCTGAAACAACTGGAGTTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
GGGTTACGTTTATATGGCTGTTTATCCGACACCGGCAGCTCCCGCAACAACCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References