Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 904929..905586 Replicon chromosome
Accession NZ_CP070598
Organism Klebsiella pneumoniae strain KPA4411

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JW306_RS06735 Protein ID WP_002916310.1
Coordinates 905176..905586 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JW306_RS06730 Protein ID WP_002916312.1
Coordinates 904929..905195 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW306_RS06705 900085..901518 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JW306_RS06710 901637..902365 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JW306_RS06715 902415..902726 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JW306_RS06720 902890..903549 + 660 WP_002916317.1 hemolysin III family protein -
JW306_RS06725 903700..904683 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JW306_RS06730 904929..905195 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JW306_RS06735 905176..905586 + 411 WP_002916310.1 protein YgfX Toxin
JW306_RS06740 905593..906114 - 522 WP_002916308.1 flavodoxin FldB -
JW306_RS06745 906215..907111 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JW306_RS06750 907134..907847 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JW306_RS06755 907853..909586 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T194471 WP_002916310.1 NZ_CP070598:905176-905586 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T194471 NZ_CP093495:c5208972-5208589 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT194471 WP_002916312.1 NZ_CP070598:904929-905195 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194471 NZ_CP093495:c5209214-5208972 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References