Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4796273..4796789 Replicon chromosome
Accession NZ_CP070586
Organism Klebsiella pneumoniae strain KP52813

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag JW304_RS25660 Protein ID WP_004178374.1
Coordinates 4796273..4796557 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JW304_RS25665 Protein ID WP_002886901.1
Coordinates 4796547..4796789 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW304_RS25635 4791690..4791998 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
JW304_RS25640 4792083..4792256 + 174 WP_019725541.1 hypothetical protein -
JW304_RS25645 4792259..4793002 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JW304_RS25650 4793359..4795497 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JW304_RS25655 4795805..4796269 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JW304_RS25660 4796273..4796557 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW304_RS25665 4796547..4796789 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JW304_RS25670 4796867..4798777 - 1911 WP_048299762.1 BglG family transcription antiterminator -
JW304_RS25675 4798800..4799954 - 1155 WP_002886900.1 lactonase family protein -
JW304_RS25680 4800021..4800761 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T194430 WP_004178374.1 NZ_CP070586:c4796557-4796273 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T194430 NZ_CP093481:4108125-4108343 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT194430 WP_002886901.1 NZ_CP070586:c4796789-4796547 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT194430 NZ_CP093481:4107724-4108098 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References