Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4081401..4082020 Replicon chromosome
Accession NZ_CP070586
Organism Klebsiella pneumoniae strain KP52813

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JW304_RS22305 Protein ID WP_002892050.1
Coordinates 4081802..4082020 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JW304_RS22300 Protein ID WP_002892066.1
Coordinates 4081401..4081775 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW304_RS22290 4076553..4077746 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JW304_RS22295 4077769..4080915 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JW304_RS22300 4081401..4081775 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JW304_RS22305 4081802..4082020 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JW304_RS22310 4082179..4082745 + 567 WP_002892030.1 maltose O-acetyltransferase -
JW304_RS22315 4082717..4082857 - 141 WP_004147370.1 hypothetical protein -
JW304_RS22320 4082878..4083348 + 471 WP_002892026.1 YlaC family protein -
JW304_RS22325 4083323..4084774 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JW304_RS22330 4084875..4085573 + 699 WP_032414604.1 GNAT family N-acetyltransferase -
JW304_RS22335 4085570..4085710 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JW304_RS22340 4085710..4085973 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T194428 WP_002892050.1 NZ_CP070586:4081802-4082020 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T194428 NZ_CP093481:2061700-2061802 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT194428 WP_002892066.1 NZ_CP070586:4081401-4081775 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT194428 NZ_CP093481:c2061809-2061664 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References