194407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4412377..4413034 Replicon chromosome
Accession NZ_CP070579
Organism Klebsiella pneumoniae strain KP52810

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JW303_RS23475 Protein ID WP_002916310.1
Coordinates 4412377..4412787 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JW303_RS23480 Protein ID WP_002916312.1
Coordinates 4412768..4413034 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW303_RS23455 4408377..4410110 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
JW303_RS23460 4410116..4410829 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JW303_RS23465 4410852..4411748 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JW303_RS23470 4411849..4412370 + 522 WP_002916308.1 flavodoxin FldB -
JW303_RS23475 4412377..4412787 - 411 WP_002916310.1 protein YgfX Toxin
JW303_RS23480 4412768..4413034 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JW303_RS23485 4413280..4414263 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JW303_RS23490 4414414..4415073 - 660 WP_002916317.1 hemolysin III family protein -
JW303_RS23495 4415237..4415548 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JW303_RS23500 4415598..4416326 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JW303_RS23505 4416445..4417878 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T194407 WP_002916310.1 NZ_CP070579:c4412787-4412377 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T194407 NZ_CP093471:c5352881-5352498 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT194407 WP_002916312.1 NZ_CP070579:c4413034-4412768 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194407 NZ_CP093471:c5353123-5352881 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References