Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1239384..1240003 Replicon chromosome
Accession NZ_CP070579
Organism Klebsiella pneumoniae strain KP52810

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JW303_RS07960 Protein ID WP_002892050.1
Coordinates 1239384..1239602 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JW303_RS07965 Protein ID WP_002892066.1
Coordinates 1239629..1240003 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW303_RS07925 1235431..1235694 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
JW303_RS07930 1235694..1235834 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JW303_RS07935 1235831..1236529 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
JW303_RS07940 1236630..1238081 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JW303_RS07945 1238056..1238526 - 471 WP_002892026.1 YlaC family protein -
JW303_RS07950 1238547..1238687 + 141 WP_004147370.1 hypothetical protein -
JW303_RS07955 1238659..1239225 - 567 WP_002892030.1 maltose O-acetyltransferase -
JW303_RS07960 1239384..1239602 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JW303_RS07965 1239629..1240003 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JW303_RS07970 1240489..1243635 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JW303_RS07975 1243658..1244851 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T194397 WP_002892050.1 NZ_CP070579:c1239602-1239384 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T194397 NZ_CP093466:55121-55603 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT194397 WP_002892066.1 NZ_CP070579:c1240003-1239629 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT194397 NZ_CP093466:54867-55133 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References