Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4382..4917 Replicon plasmid p52808_2
Accession NZ_CP070574
Organism Proteus mirabilis strain PM52808

Toxin (Protein)


Gene name relE Uniprot ID A0A218N496
Locus tag JW302_RS19500 Protein ID WP_036896464.1
Coordinates 4630..4917 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A218N4B4
Locus tag JW302_RS19495 Protein ID WP_036896461.1
Coordinates 4382..4633 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW302_RS19470 1800..2087 - 288 WP_036896447.1 TrbC/VirB2 family protein -
JW302_RS19475 2097..2711 - 615 WP_036896450.1 transglycosylase SLT domain-containing protein -
JW302_RS19480 2708..2890 - 183 WP_036896454.1 hypothetical protein -
JW302_RS19485 3046..3312 - 267 WP_142836830.1 hypothetical protein -
JW302_RS19490 3567..3977 - 411 WP_036896458.1 replication/maintenance protein RepL -
JW302_RS19495 4382..4633 + 252 WP_036896461.1 antitoxin Antitoxin
JW302_RS19500 4630..4917 + 288 WP_036896464.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW302_RS19505 5008..6171 - 1164 WP_036896467.1 relaxase/mobilization nuclease domain-containing protein -
JW302_RS19510 6180..6728 - 549 WP_036896470.1 hypothetical protein -
JW302_RS19515 7532..7864 - 333 WP_036896473.1 hypothetical protein -
JW302_RS19520 7959..8156 - 198 WP_049195515.1 helix-turn-helix domain-containing protein -
JW302_RS19525 8149..8379 - 231 WP_036896410.1 hypothetical protein -
JW302_RS19530 8392..8550 - 159 WP_153274249.1 hypothetical protein -
JW302_RS19535 8553..9110 - 558 WP_036896412.1 hypothetical protein -
JW302_RS19540 9161..9676 - 516 WP_036896414.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1D - 1..40918 40918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11135.24 Da        Isoelectric Point: 10.6493

>T194388 WP_036896464.1 NZ_CP070574:4630-4917 [Proteus mirabilis]
MMYSVKFRKDAEKEWKKLDKTIQSQFAKQLIKRCENPHVASAKLRNMPNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
REKSQVYNLASERLK

Download         Length: 288 bp

>T194388 NZ_CP093465:348446-349363 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.45 Da        Isoelectric Point: 4.0548

>AT194388 WP_036896461.1 NZ_CP070574:4382-4633 [Proteus mirabilis]
MPNTILSDTTASVSELKKNPMATVNAGLGYPVAILNRNQPAFYCVPAELYEQILDALDDNELAKLVKERESQPLVDINLA
EYL

Download         Length: 252 bp

>AT194388 NZ_CP093465:347682-348440 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A218N496

Antitoxin

Source ID Structure
AlphaFold DB A0A218N4B4

References