Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4041492..4042293 Replicon chromosome
Accession NZ_CP070572
Organism Proteus mirabilis strain PM52808

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag JW302_RS18820 Protein ID WP_001094437.1
Coordinates 4041492..4041869 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag JW302_RS18825 Protein ID WP_001390338.1
Coordinates 4041916..4042293 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW302_RS18790 4036915..4037235 - 321 WP_004246668.1 helix-turn-helix transcriptional regulator -
JW302_RS18795 4038006..4038158 + 153 Protein_3654 transposase -
JW302_RS18800 4038283..4039317 - 1035 WP_017628609.1 virulence RhuM family protein -
JW302_RS18805 4039860..4040705 - 846 WP_001274561.1 DUF4942 domain-containing protein -
JW302_RS18810 4040790..4040987 - 198 WP_000772032.1 DUF957 domain-containing protein -
JW302_RS18815 4041007..4041495 - 489 WP_000761716.1 hypothetical protein -
JW302_RS18820 4041492..4041869 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
JW302_RS18825 4041916..4042293 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JW302_RS18830 4042456..4042677 - 222 WP_000692345.1 DUF987 domain-containing protein -
JW302_RS18835 4042740..4043216 - 477 WP_001535682.1 RadC family protein -
JW302_RS18840 4043232..4043705 - 474 WP_000855064.1 antirestriction protein -
JW302_RS18845 4044047..4044865 - 819 WP_001535681.1 DUF945 domain-containing protein -
JW302_RS18850 4045020..4045178 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T194387 WP_001094437.1 NZ_CP070572:c4041869-4041492 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T194387 NZ_CP093465:23624-24007 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT194387 WP_001390338.1 NZ_CP070572:c4042293-4041916 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT194387 NZ_CP093465:23382-23624 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References