Detailed information of TA system TA194386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3878099..3878798
• Replicon: chromosome
• Accession: NZ_CP070572
• Organism: Proteus mirabilis strain PM52808

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JW302_RS18070
• Protein ID: WP_017628658.1
• Coordinates: 3878099..3878485 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: JW302_RS18075
• Protein ID: WP_004246828.1
• Coordinates: 3878478..3878798 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW302_RS18055	3874118..3874699	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
JW302_RS18060	3874950..3875855	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
JW302_RS18065	3875865..3877937	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
JW302_RS18070	3878099..3878485	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JW302_RS18075	3878478..3878798	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
JW302_RS18080	3878847..3879281	-	435	WP_004246827.1	hypothetical protein	-
JW302_RS18085	3879274..3880158	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
JW302_RS18090	3880373..3881659	-	1287	WP_063073863.1	DUF3748 domain-containing protein	-
JW302_RS18095	3881796..3882413	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
JW302_RS18100	3882714..3883337	+	624	WP_004246821.1	guanylate kinase	-
JW302_RS18105	3883392..3883667	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T194386 WP_017628658.1 NZ_CP070572:3878099-3878485 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T194386 NZ_CP093460:36363-36845 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT194386 WP_004246828.1 NZ_CP070572:3878478-3878798 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT194386 NZ_CP093460:36109-36375 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: B4EZ97