Detailed information of TA system TA194384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 2799923..2800458
• Replicon: chromosome
• Accession: NZ_CP070572
• Organism: Proteus mirabilis strain PM52808

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JW302_RS13355
• Protein ID: WP_205507924.1
• Coordinates: 2800189..2800458 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E2GHF7
• Locus tag: JW302_RS13350
• Protein ID: WP_012881119.1
• Coordinates: 2799923..2800192 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW302_RS13295	2795316..2795588	+	273	WP_071233776.1	hypothetical protein	-
JW302_RS13300	2795632..2795856	+	225	WP_162778485.1	hypothetical protein	-
JW302_RS13305	2795928..2796083	+	156	WP_183129929.1	hypothetical protein	-
JW302_RS13310	2796091..2796345	+	255	WP_063073719.1	hypothetical protein	-
JW302_RS13315	2796342..2796563	+	222	WP_049199148.1	hypothetical protein	-
JW302_RS13320	2796560..2797486	+	927	WP_063073718.1	recombinase RecT	-
JW302_RS13325	2797526..2798146	+	621	WP_049206325.1	hypothetical protein	-
JW302_RS13330	2798139..2798840	+	702	WP_096043072.1	YqaJ viral recombinase family protein	-
JW302_RS13335	2798830..2799327	+	498	Protein_2592	single-stranded DNA-binding protein	-
JW302_RS13340	2799385..2799549	+	165	WP_121909455.1	hook protein	-
JW302_RS13345	2799585..2799878	+	294	WP_205507923.1	hypothetical protein	-
JW302_RS13350	2799923..2800192	+	270	WP_012881119.1	ABC transporter ATPase	Antitoxin
JW302_RS13355	2800189..2800458	+	270	WP_205507924.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JW302_RS13360	2800504..2801352	+	849	WP_012881117.1	3'-5' exonuclease	-
JW302_RS13365	2801469..2801951	+	483	WP_001311056.1	hypothetical protein	-
JW302_RS13370	2801980..2803464	-	1485	WP_016240487.1	IS5 family transposase	-
JW302_RS13375	2803544..2804419	-	876	WP_001617865.1	class A extended-spectrum beta-lactamase CTX-M-14	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	blaCTX-M-14	-	2754378..2809481	55103
	-	flank	IS/Tn	blaCTX-M-14	-	2803544..2805931	2387

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10411.93 Da
• Isoelectric Point: 7.3149

>T194384 WP_205507924.1 NZ_CP070572:2800189-2800458 [Proteus mirabilis]
MMEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YMHTAQKWP

Nucleotide

• Length: 270 bp

>T194384 NZ_CP093459:227686-227991 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCTGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10206.54 Da
• Isoelectric Point: 8.8735

>AT194384 WP_012881119.1 NZ_CP070572:2799923-2800192 [Proteus mirabilis]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK

Nucleotide

• Length: 270 bp

>AT194384 NZ_CP093459:227466-227684 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGAATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4Y1YSD8