Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 114338..114939 Replicon chromosome
Accession NZ_CP070572
Organism Proteus mirabilis strain PM52808

Toxin (Protein)


Gene name doc Uniprot ID A0A7D6AHD8
Locus tag JW302_RS00505 Protein ID WP_063073825.1
Coordinates 114338..114721 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7D5W489
Locus tag JW302_RS00510 Protein ID WP_063073826.1
Coordinates 114718..114939 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW302_RS00485 110270..110833 + 564 WP_063073823.1 methyltransferase -
JW302_RS00490 111109..112008 + 900 WP_063073824.1 N-acetylmuramic acid 6-phosphate etherase -
JW302_RS00495 112365..113603 - 1239 WP_004246499.1 HipA domain-containing protein -
JW302_RS00500 113616..113930 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
JW302_RS00505 114338..114721 - 384 WP_063073825.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JW302_RS00510 114718..114939 - 222 WP_063073826.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JW302_RS00515 115184..116047 - 864 WP_063073829.1 YicC family protein -
JW302_RS00520 116174..116890 + 717 WP_004249946.1 ribonuclease PH -
JW302_RS00525 116972..117616 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
JW302_RS00530 117935..118540 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
JW302_RS00535 118660..119118 - 459 WP_063073830.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14485.56 Da        Isoelectric Point: 8.5126

>T194381 WP_063073825.1 NZ_CP070572:c114721-114338 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVEQLAKHLQNLVEKTN

Download         Length: 384 bp

>T194381 NZ_CP093458:c4616894-4616610 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8290.25 Da        Isoelectric Point: 5.5667

>AT194381 WP_063073826.1 NZ_CP070572:c114939-114718 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNTKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT194381 NZ_CP093458:c4617126-4616884 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6AHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5W489

References