Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 16746..17281 Replicon plasmid p52260_1
Accession NZ_CP070570
Organism Proteus mirabilis strain PM52260

Toxin (Protein)


Gene name relE Uniprot ID A0A218N496
Locus tag JW301_RS19555 Protein ID WP_036896464.1
Coordinates 16746..17033 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A218N4B4
Locus tag JW301_RS19560 Protein ID WP_036896461.1
Coordinates 17030..17281 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW301_RS19515 11987..12502 + 516 WP_036896414.1 J domain-containing protein -
JW301_RS19520 12553..13110 + 558 WP_036896412.1 hypothetical protein -
JW301_RS19525 13113..13271 + 159 WP_153274249.1 hypothetical protein -
JW301_RS19530 13284..13514 + 231 WP_036896410.1 hypothetical protein -
JW301_RS19535 13507..13704 + 198 WP_049195515.1 helix-turn-helix domain-containing protein -
JW301_RS19540 13799..14131 + 333 WP_036896473.1 hypothetical protein -
JW301_RS19545 14935..15483 + 549 WP_036896470.1 hypothetical protein -
JW301_RS19550 15492..16655 + 1164 WP_036896467.1 relaxase/mobilization nuclease domain-containing protein -
JW301_RS19555 16746..17033 - 288 WP_036896464.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW301_RS19560 17030..17281 - 252 WP_036896461.1 antitoxin Antitoxin
JW301_RS19565 17686..18096 + 411 WP_036896458.1 replication/maintenance protein RepL -
JW301_RS19570 18351..18617 + 267 WP_142836830.1 hypothetical protein -
JW301_RS19575 18773..18955 + 183 WP_036896454.1 hypothetical protein -
JW301_RS19580 18952..19566 + 615 WP_036896450.1 transglycosylase SLT domain-containing protein -
JW301_RS19585 19576..19863 + 288 WP_036896447.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1D - 1..40918 40918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11135.24 Da        Isoelectric Point: 10.6493

>T194378 WP_036896464.1 NZ_CP070570:c17033-16746 [Proteus mirabilis]
MMYSVKFRKDAEKEWKKLDKTIQSQFAKQLIKRCENPHVASAKLRNMPNCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
REKSQVYNLASERLK

Download         Length: 288 bp

>T194378 NZ_CP093458:c3742765-3742448 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.45 Da        Isoelectric Point: 4.0548

>AT194378 WP_036896461.1 NZ_CP070570:c17281-17030 [Proteus mirabilis]
MPNTILSDTTASVSELKKNPMATVNAGLGYPVAILNRNQPAFYCVPAELYEQILDALDDNELAKLVKERESQPLVDINLA
EYL

Download         Length: 252 bp

>AT194378 NZ_CP093458:c3742455-3742168 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A218N496

Antitoxin

Source ID Structure
AlphaFold DB A0A218N4B4

References