Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3878018..3878717 Replicon chromosome
Accession NZ_CP070569
Organism Proteus mirabilis strain PM52260

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JW301_RS18080 Protein ID WP_017628658.1
Coordinates 3878018..3878404 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag JW301_RS18085 Protein ID WP_004246828.1
Coordinates 3878397..3878717 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW301_RS18065 3874037..3874618 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
JW301_RS18070 3874869..3875774 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
JW301_RS18075 3875784..3877856 + 2073 WP_017628659.1 glycine--tRNA ligase subunit beta -
JW301_RS18080 3878018..3878404 + 387 WP_017628658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JW301_RS18085 3878397..3878717 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
JW301_RS18090 3878766..3879200 - 435 WP_004246827.1 hypothetical protein -
JW301_RS18095 3879193..3880077 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
JW301_RS18100 3880292..3881578 - 1287 WP_063073863.1 DUF3748 domain-containing protein -
JW301_RS18105 3881715..3882332 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
JW301_RS18110 3882633..3883256 + 624 WP_004246821.1 guanylate kinase -
JW301_RS18115 3883311..3883586 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14322.65 Da        Isoelectric Point: 10.0826

>T194376 WP_017628658.1 NZ_CP070569:3878018-3878404 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Download         Length: 387 bp

>T194376 NZ_CP093458:1893770-1893872 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT194376 WP_004246828.1 NZ_CP070569:3878397-3878717 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT194376 NZ_CP093458:c1893879-1893734 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References