Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelE-RHH |
| Location | 2799837..2800372 | Replicon | chromosome |
| Accession | NZ_CP070569 | ||
| Organism | Proteus mirabilis strain PM52260 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | JW301_RS13365 | Protein ID | WP_205507924.1 |
| Coordinates | 2800103..2800372 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | E2GHF7 |
| Locus tag | JW301_RS13360 | Protein ID | WP_012881119.1 |
| Coordinates | 2799837..2800106 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JW301_RS13305 | 2795230..2795502 | + | 273 | WP_071233776.1 | hypothetical protein | - |
| JW301_RS13310 | 2795546..2795770 | + | 225 | WP_162778485.1 | hypothetical protein | - |
| JW301_RS13315 | 2795842..2795997 | + | 156 | WP_183129929.1 | hypothetical protein | - |
| JW301_RS13320 | 2796005..2796259 | + | 255 | WP_063073719.1 | hypothetical protein | - |
| JW301_RS13325 | 2796256..2796477 | + | 222 | WP_049199148.1 | hypothetical protein | - |
| JW301_RS13330 | 2796474..2797400 | + | 927 | WP_063073718.1 | recombinase RecT | - |
| JW301_RS13335 | 2797440..2798060 | + | 621 | WP_049206325.1 | hypothetical protein | - |
| JW301_RS13340 | 2798053..2798754 | + | 702 | WP_096043072.1 | YqaJ viral recombinase family protein | - |
| JW301_RS13345 | 2798744..2799241 | + | 498 | Protein_2594 | single-stranded DNA-binding protein | - |
| JW301_RS13350 | 2799299..2799463 | + | 165 | WP_121909455.1 | hook protein | - |
| JW301_RS13355 | 2799499..2799792 | + | 294 | WP_205507923.1 | hypothetical protein | - |
| JW301_RS13360 | 2799837..2800106 | + | 270 | WP_012881119.1 | ABC transporter ATPase | Antitoxin |
| JW301_RS13365 | 2800103..2800372 | + | 270 | WP_205507924.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JW301_RS13370 | 2800418..2801266 | + | 849 | WP_012881117.1 | 3'-5' exonuclease | - |
| JW301_RS13375 | 2801383..2801865 | + | 483 | WP_001311056.1 | hypothetical protein | - |
| JW301_RS13380 | 2801894..2803378 | - | 1485 | WP_016240487.1 | IS5 family transposase | - |
| JW301_RS13385 | 2803458..2804333 | - | 876 | WP_001617865.1 | class A extended-spectrum beta-lactamase CTX-M-14 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | blaCTX-M-14 | - | 2754292..2809395 | 55103 | |
| - | flank | IS/Tn | blaCTX-M-14 | - | 2803458..2805845 | 2387 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10411.93 Da Isoelectric Point: 7.3149
>T194374 WP_205507924.1 NZ_CP070569:2800103-2800372 [Proteus mirabilis]
MMEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YMHTAQKWP
MMEIFWTILASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YMHTAQKWP
Download Length: 270 bp
>T194374 NZ_CP093458:759496-759981 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10206.54 Da Isoelectric Point: 8.8735
>AT194374 WP_012881119.1 NZ_CP070569:2799837-2800106 [Proteus mirabilis]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSATAWRD
EISRKVAGK
Download Length: 270 bp
>AT194374 NZ_CP093458:759206-759499 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|