Detailed information of TA system TA194372

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1681779..1682424
• Replicon: chromosome
• Accession: NZ_CP070569
• Organism: Proteus mirabilis strain PM52260

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: JW301_RS07920
• Protein ID: WP_004247035.1
• Coordinates: 1682239..1682424 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: JW301_RS07915
• Protein ID: WP_004247034.1
• Coordinates: 1681779..1682192 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW301_RS07885	1677332..1677490	-	159	WP_004247025.1	hypothetical protein	-
JW301_RS07890	1677942..1678118	+	177	WP_004247793.1	hypothetical protein	-
JW301_RS07895	1678289..1679035	-	747	WP_017628402.1	methyltransferase domain-containing protein	-
JW301_RS07900	1679885..1680463	+	579	WP_017628400.1	alpha/beta hydrolase	-
JW301_RS07905	1680576..1680869	-	294	Protein_1525	LysE family transporter	-
JW301_RS07910	1681183..1681683	-	501	WP_004247032.1	response regulator	-
JW301_RS07915	1681779..1682192	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JW301_RS07920	1682239..1682424	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
JW301_RS07925	1682535..1683305	+	771	Protein_1529	DUF1073 domain-containing protein	-
JW301_RS07930	1683864..1684415	-	552	WP_017628396.1	PH domain-containing protein	-
JW301_RS07935	1684479..1684793	-	315	WP_017628395.1	hypothetical protein	-
JW301_RS07945	1685200..1686933	-	1734	WP_017628394.1	LPS biosynthesis-modulating metalloenzyme YejM	-
JW301_RS07950	1686957..1687184	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1676549..1694406	17857

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T194372 WP_004247035.1 NZ_CP070569:c1682424-1682239 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T194372 NZ_CP093454:c15979-15629 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT194372 WP_004247034.1 NZ_CP070569:c1682192-1681779 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT194372 NZ_CP093454:c15624-15322 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85