Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 114254..114855 Replicon chromosome
Accession NZ_CP070569
Organism Proteus mirabilis strain PM52260

Toxin (Protein)


Gene name doc Uniprot ID A0A7D6AHD8
Locus tag JW301_RS00505 Protein ID WP_063073825.1
Coordinates 114254..114637 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7D5W489
Locus tag JW301_RS00510 Protein ID WP_063073826.1
Coordinates 114634..114855 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW301_RS00485 110186..110749 + 564 WP_063073823.1 methyltransferase -
JW301_RS00490 111025..111924 + 900 WP_063073824.1 N-acetylmuramic acid 6-phosphate etherase -
JW301_RS00495 112281..113519 - 1239 WP_004246499.1 HipA domain-containing protein -
JW301_RS00500 113532..113846 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
JW301_RS00505 114254..114637 - 384 WP_063073825.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JW301_RS00510 114634..114855 - 222 WP_063073826.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JW301_RS00515 115100..115963 - 864 WP_063073829.1 YicC family protein -
JW301_RS00520 116090..116806 + 717 WP_004249946.1 ribonuclease PH -
JW301_RS00525 116888..117532 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
JW301_RS00530 117851..118456 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
JW301_RS00535 118576..119034 - 459 WP_063073830.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14485.56 Da        Isoelectric Point: 8.5126

>T194371 WP_063073825.1 NZ_CP070569:c114637-114254 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVEQLAKHLQNLVEKTN

Download         Length: 384 bp

>T194371 NZ_CP093452:37301-37717 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8290.25 Da        Isoelectric Point: 5.5667

>AT194371 WP_063073826.1 NZ_CP070569:c114855-114634 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNTKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT194371 NZ_CP093452:37074-37304 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6AHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5W489

References