Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4277510..4278167 Replicon chromosome
Accession NZ_CP070564
Organism Klebsiella pneumoniae strain KP51069

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JW299_RS22910 Protein ID WP_002916310.1
Coordinates 4277510..4277920 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JW299_RS22915 Protein ID WP_002916312.1
Coordinates 4277901..4278167 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW299_RS22890 4273510..4275243 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
JW299_RS22895 4275249..4275962 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JW299_RS22900 4275985..4276881 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JW299_RS22905 4276982..4277503 + 522 WP_002916308.1 flavodoxin FldB -
JW299_RS22910 4277510..4277920 - 411 WP_002916310.1 protein YgfX Toxin
JW299_RS22915 4277901..4278167 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JW299_RS22920 4278413..4279396 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JW299_RS22925 4279547..4280206 - 660 WP_002916317.1 hemolysin III family protein -
JW299_RS22930 4280370..4280681 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
JW299_RS22935 4280731..4281459 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JW299_RS22940 4281578..4283011 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T194346 WP_002916310.1 NZ_CP070564:c4277920-4277510 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T194346 NZ_CP093445:314275-314643 [Salmonella enterica subsp. enterica serovar Abeokuta]
ATGACCTTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACAGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT194346 WP_002916312.1 NZ_CP070564:c4278167-4277901 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT194346 NZ_CP093445:314057-314278 [Salmonella enterica subsp. enterica serovar Abeokuta]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References