Detailed information of TA system TA194337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2428840..2430428
• Replicon: chromosome
• Accession: NZ_CP070564
• Organism: Klebsiella pneumoniae strain KP51069

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: W8UI36
• Locus tag: JW299_RS13730
• Protein ID: WP_002904792.1
• Coordinates: 2429106..2430428 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: JW299_RS13725
• Protein ID: WP_002904790.1
• Coordinates: 2428840..2429106 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JW299_RS13700	2423990..2424913	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
JW299_RS13705	2424894..2426048	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
JW299_RS13710	2426394..2427773	+	1380	WP_002904785.1	purine permease	-
JW299_RS13715	2427751..2428251	+	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
JW299_RS13720	2428248..2428574	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
JW299_RS13725	2428840..2429106	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
JW299_RS13730	2429106..2430428	+	1323	WP_002904792.1	type II toxin-antitoxin system HipA family toxin	Toxin
JW299_RS13735	2430445..2431737	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
JW299_RS13740	2431879..2432883	-	1005	WP_002904798.1	type 1 fimbrial protein	-
JW299_RS13745	2432871..2435372	-	2502	WP_004151634.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T194337 WP_002904792.1 NZ_CP070564:2429106-2430428 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T194337 NZ_CP093428:250354-250536 [Pseudomonas migulae]
ATGCGAAGTCGGGAAATGATCAGGATGATCGAAGAGGGTGGTTGGTATCTGGTGGCCGTGAGAGGTAGCCACCATCAGTA
CAAGCATTTGTACAAGGCTGGCCGGGTGACGATTAAGCATCCTGATTCGGATCTTCCAAAAGGTACGATCAACAGCATTT
TGAAACAGGCGGGCCTTAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT194337 WP_002904790.1 NZ_CP070564:2428840-2429106 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT194337 NZ_CP093428:250596-250997 [Pseudomonas migulae]
ATGAAATTCCCGGTCGTTCTGCACAAGGATGCCGACTCAGAATACGGAGTGATAATCCCGGACGTGCCGGGTTGTTTCTC
TGCGGGCGCTACAGTGGCGCAGGCATTCGAAAACGTGAAGGAGGCGTTGTCCTTGCACTATGAGGGGTTGGTCGCTGATG
GTGATCCACTGCCGCAAGTGCAGGAGATAGACGCTCATATTGATAACCCTGATTACGCCGGCGGTGTGTGGGGTGTGGTT
GACTTCGATATCACGCCTTACTTTGGCAAGTCGGTTCGCTTCAATGCCACTCTGCCTGAGCAGTTGCTTGAGCGTATCGA
TCAAACGGTCAGGCGAGATCAGCGATACAGCTCAAGATCCGGCTTTTTGGCGGCGGCCGCACTGCGTGAGCTATCGGCAT
AA

Structures

Toxin

• AlphaFold DB: A0A0E1CEC8

Antitoxin

• AlphaFold DB: A0A0H3GXD8